Useful Articles Page 2

A very long list of Medically related CD info.

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Candidate gene regions and genetic heterogeneity in gluten sensitivity.

Gluten sensitivity is a common multifactorial disorder, manifested in the small intestine or on the skin as typical coeliac disease or dermatitis herpetiformis, respectively. The only established genetic risk factor is HLA DQ2.

Click Here to read PubMed article


Putting the Healthy back into the Gluten-Free Diet

Nutrition educators instructing patients on the gluten-free diet tend to place an emphasis on a “don’t list,” often leaving out the important message of eating a nutritionally adequate and healthy diet.

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Genetic basis for Alopecia Areata discovered

For years, alopecia areata was thought to be related to psoriasis because both are inflammatory diseases where T cells attack the skin.
For this reason, psoriasis drugs have been tested in clinical trials for alopecia areata, but without much success.
In this research, Dr. Christiano and her team found few genes in common to both diseases. Rather, they showed that alopecia areata genes have more in common with those implicated in rheumatoid arthritis, coeliac disease, and type 1 diabetes.

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Coeliac Disease the past, present and future

The Coeliac Disease Road Map

The Past and Present .. Click Here

PDF presentations by Dr. Alessio Fasano

The Future .. Click Here


Fingernail irregularities and autoimmune diseases

Abnormalities of the nail are often caused by skin infection (most often fungal) but may also indicate more general medical conditions.
This discussion does not address localized trauma or nail infections
but offers examples of nail abnormalities that may occur with systemic disease.

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Sleep Disorders in CD and Autoimmune Disease

Obstructive sleep apnea,
restless leg syndrome,
and periodic limb movement disorder
occur in association with CD and various autoimmune disorders

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Intestinal Dysbiosis

Intestinal dysbiosis, the growth of unfriendly organisms or overgrowth of normally harmless organisms in the gastrointestinal tract, is a widespread but frequently unrecognized cause of chronic disorders throughout the body.
Among the Frequent Signs and Symptoms.
Frequent indigestion
Nausea after taking supplements
Food allergies or intolerances
Coeliac disease
Autoimmune diseases
Risk increases with (a small selection)
Food allergies
Antibiotic/drug therapy
Decreased immune function

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What Causes Vitamin Deficiency Anemia

When the body is underprovided in certain key vitamins, a type of anemia called vitamin deficiency anemia can develop.
Anemia goes undetected in many people, and symptoms can be minor or vague.
The signs and symptoms can be related to the anemia itself, or the underlying cause.
Most commonly, people with anemia report non-specific symptoms of a feeling of weakness, or fatigue, general malaise and sometimes poor concentration.

Among the many complications:

Mental confusion or forgetfulness
Muscle weakness
Numbness or tingling in hands and feet

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Coeliac Diease and the Irish dimension

Perhaps the only advantage of Oliver Cromwell invasion of Ireland was that his staff included a Colonel Graves, from whom Dr. Robert Graves descended. (Graves Disease)

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From the Neolithic Revolution to the Gluten Intolerance:

We have recently reported on Lancet (1) a consistent cohort of patients affected by drug-resistant epilepsy with cerebral calcifications, half of which were cured by a gluten-free diet. All had an atrophic jejunal mucosa, which recovered on a gluten free diet. Gluten intolerance is now a recognized cause of brain calcifications and epilepsy, of dementia, of psychiatric disturbances: many researchers believe that, in genetically predisposed subjects, gluten is not healthy for the brain function (2).
This is just too much.
Having had over 25 years of variegated experience with gluten intolerance I find hard to imagine that the single most common food intolerance to the single most diffuse staple food in our environment might provoke such a complexity of severe adverse immuno-mediated reactions in any part of the human body and function. The list is endless, but malignancies, adverse pregnancy outcome and impaired brain function are indeed complications above the tolerable threshold of this food intolerance.
On the other end today we know very well that the majority (as many as 9 to 1) of gluten intolerant subjects, identified by familial or population screening, do not manifest any complaint, although they do have a flat intestinal mucosa (3).

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