Coeliac Disease – Sinusitis – Histamines – Asthma – Dry Skin
Antibiotics turn short term sinus infections into chronic ones.
To get to the root of sinus infections, and eliminate them, treat the underlying fungal/candida infections.
In addition, as sinus infections likely exist in what are called “Biofilms,” oral antibiotics don’t work, but special sprays can be very effective.
Although we have discussed some unusual viral and bacterial infections associated with the immune dysfunction of CFS/FMS, these illnesses are also associated with more of the day-to-day variety of infections.
These include chronic sinusitis.
In today’s article we will talk about how to treat chronic sinusitis—whether or not you have CFS/FMS.
Tissue Transglutaminase-Mediated Formation and Cleavage of Histamine-Gliadin Complexes: Biological Effects and Implications for Coeliac Disease
Coeliac disease is an HLA-DQ2-associated disorder characterized by an intestinal T cell response.
The disease-relevant T cells secrete IFN-ã upon recognition of gluten peptides that have been deamidated in vivo by the enzyme tissue transglutaminase (transglutaminase 2 (TG2)).
The coeliac intestinal mucosa contains elevated numbers of mast cells, and increased histamine secretion has been reported in celiac patients.
This appears paradoxical because histamine typically biases T cell responses in the direction of Th2 instead of the Th1 pattern seen in the celiac lesions.
We report that histamine is an excellent substrate for TG2, and it can be efficiently conjugated to gluten peptides through TG2-mediated transamidation.
Histamine-peptide conjugates do not exert agonistic effects on histamine receptors, and scavenging of biologically active histamine by gluten peptide conjugation can have physiological implications and may contribute to the mucosal IFN-ã response in active disease.
Interestingly, TG2 is able to hydrolyze the peptide-histamine conjugates when the concentrations of substrates are lowered, thereby releasing deamidated gluten peptides that are stimulatory to T cells.
Coeliac Disease & Asthma appear to be linked.
If you have asthma it may be worthwhile eating gluten free to ease your breathing problems?
The link between coeliac disease and asthma has been as difficult to prove as finding the reason coeliac disease exists.
However some tangible evidence (statistical relationships) have been found.
The majority of articles suggest there is no link between coeliac disease and asthma, while anecdotal evidence from coeliacs suggests that their asthma increases dramatically after the ingestion of any gluten foods.
For instance, an article by Dr Pradeep Bhandari (Ref 1) says that “Coeliac disease and Asthma tend to run in families and the tendency to get these diseases is inherited genetically.
However, they are not inter-linked.
The tendency to get coeliac disease is inherited genetically.
It mostly affects people of European descent.
It is also more common in families with Diabetes or rheumatoid Arthritis.
Something in the environment is necessary to trigger the coeliac disease in those who are susceptible.
Asthma tends to run in families.
A person with a parent who has Asthma is three to six times more likely to develop Asthma than someone who does not’t have a parent with Asthma. But no single gene is responsible for Asthma. Instead, you may inherit a general predisposition to Asthma”
Coeliac Disease Linked to Many Skin Conditions
Eczema, Psoriasis and Hives Occur More Often in Coeliacs
Coeliac Disease affects more than just your digestive system — it also may affect your skin.
Around 15% to 25% of coeliacs suffer from dermatitis herpetiformis, a rash considered the skin manifestation of celiac disease.
But this is by no means the only skin problem people with celiac disease may have.
Eczema, psoriasis, acne, chronic dry skin, hives and alopecia areata are possible, too.
For some reason, they affect celiacs more often than the general population.
Although there’s currently little clear medical evidence that consuming gluten actually causes these skin conditions, in some cases people have found relief by following the Gluten Free Diet.
It makes you wonder if all our little niggling illnesses and discomforts were really early warning signs of Coeliac Disease that we and the medical profession missed.
I developed Asthma after a bad bout of flu, I suffered desperately with Rhinitis/Sinusitis so much so that I was put on anti-histamine tablets and nasal sprays and when that didn’t work I was given Steroid injections, which now seem linked to Osteoporosis and Diabetes.
As far back as I can remember I was suffering with Acid Reflux, living for years on baking soda and milk, Malox and finally Nexium tablets.
I had no idea they were all inter – related.
So, while we may be treating one problem we may be creating a multitude of others.